EMMA – Endometrial Microbiome Metagenomic Analysis
EMMA TEST
EMMA (Endometrial Microbiome Metagenomic Analysis) is an advanced diagnostic test used to evaluate the bacterial environment (microbiome) of the uterus. It identifies both beneficial and harmful bacteria present in the endometrium and helps optimize uterine health for successful embryo implantation.
At Freya Fertility, EMMA is used to ensure that the uterine environment is in its healthiest state before embryo transfer, improving pregnancy outcomes
EMMA is beneficial for patients who:
- Have recurrent implantation failure
- Have repeated IVF failures
- Have unexplained infertility
- Have suspected uterine infections
- Want to optimize uterine conditions before IVF
WHY EMMA IS IMPORTANT
Even with good-quality embryos, implantation may fail if the uterine environment is not healthy.
👉 Studies show that 30% of infertile women have potentially harmful bacteria in their endometrium
- A healthy uterus requires a balanced microbiome
- Harmful bacteria can disrupt implantation
- Undetected infections may lead to IVF failure
EMMA helps detect these hidden issues and guides proper treatment.
WHAT IS THE ENDOMETRIUM & WHY IT MATTERS
The endometrium is the inner lining of the uterus where the embryo implants and grows during pregnancy. Every month, it prepares itself to receive an embryo.
A healthy endometrium:
- Supports embryo implantation
- Maintains pregnancy
- Contains beneficial bacteria essential for reproductive health
WHAT IS ENDOMETRIAL MICROBIOME (FLORA)?
The endometrial microbiome refers to the community of microorganisms present in the uterus.
- Includes both good bacteria (like Lactobacillus) and harmful bacteria
- Plays a crucial role in implantation success
- Imbalance (dysbiosis) can lead to infertility or implantation failure
WHAT IS EMMA TEST?
EMMA analyzes the endometrial microbiota using advanced molecular techniques to:
- Detect the most common bacteria present in the uterus
- Identify beneficial vs harmful bacteria
- Evaluate whether the uterine environment is optimal for implantation
👉 EMMA also integrates ALICE testing, which detects bacteria linked to chronic endometritis.
👉 The upgraded EMMA panel:
- Developed using 70,000+ clinical samples over 5 years
- Identifies bacteria at the species level
- Allows more precise and targeted treatment
HOW EMMA HELPS IN FERTILITY
EMMA improves IVF success by:
- Detecting hidden infections or imbalance
- Improving uterine microbiome health
- Enhancing implantation conditions
- Guiding targeted antibiotic or probiotic treatment
- Increasing chances of successful pregnancy
WHY CHOOSE EMMA?
- Most comprehensive microbiome testing panel
- Identifies bacteria at species level
- Includes detection of chronic endometritis (via ALICE)
- Provides targeted treatment recommendations
- Improves uterine health before embryo transfer
Cycle Planning
The test is scheduled during a natural or mock cycle, similar to embryo transfer timing.
Endometrial Sample Collection
A small sample of the uterine lining is collected using a thin catheter: Quick procedure (few minutes) Mild discomfort may occur No anesthesia usually required
Laboratory Analysis (RT-PCR Technology)
The sample is analyzed using advanced RT-PCR technology to: Identify bacterial species present Measure quantity of bacteria Detect both beneficial and pathogenic microorganisms
Microbiome Evaluation Report
The report determines whether the uterine environment is: Optimal (healthy microbiome) Non-optimal (imbalance or infection present)
Personalized Treatment Recommendation
If imbalance is detected: Targeted antibiotics may be prescribed Probiotics may be recommended Treatment is customized based on bacterial profile
Follow-Up & Embryo Transfer Planning
After restoring microbiome balance, embryo transfer is scheduled for improved success.
Freya Fertility
Our Success Highlights
Improvement in implantation rates after microbiome correction
Increase in pregnancy success in patients with uterine imbalance
Committed to Your Parenthood Journey
At Freya Fertility, we focus on every factor that affects implantation success, including the uterine microbiome. With EMMA testing, we ensure a healthy uterine environment, improving your chances of a successful pregnancy.
FAQs
What is EMMA test?
It is a test that analyzes the bacterial environment of the uterus to improve fertility outcomes.
Why is the uterine microbiome important?
A healthy microbiome supports implantation and reduces the risk of IVF failure.
Is EMMA test painful?
It involves a minor biopsy, which may cause mild discomfort.
Can microbiome imbalance be treated?
Yes, with targeted antibiotics or probiotics, balance can be restored.
Who should consider EMMA?
Patients with repeated IVF failures, implantation issues, or unexplained infertility.