ALICE – Analysis of Infectious Chronic Endometritis
WHAT IS ALICE TEST ?
ALICE (Analysis of Infectious Chronic Endometritis) is an advanced diagnostic test designed to detect bacteria responsible for chronic endometritis—an often silent infection of the uterine lining that can negatively affect implantation and pregnancy success.
At Freya Fertility, ALICE helps identify hidden infections and provides targeted treatment to restore uterine health and improve reproductive outcomes.
ALICE is beneficial for patients who:
- Have recurrent implantation failure (RIF)
- Have repeated IVF failures
- Have recurrent miscarriages
- Have unexplained infertility
- Want to ensure a healthy uterine environment before embryo transfer
WHY ALICE IS IMPORTANT
Even when good-quality embryos are transferred, implantation can fail if the uterine environment is not healthy.
👉 Studies show:
- Up to 30% of infertile patients may have chronic endometritis
- Around 20% of infertility cases are linked to endometrial factors
Chronic endometritis often has no visible symptoms, making it difficult to detect without advanced testing.
WHAT IS THE ENDOMETRIUM?
The endometrium is the inner lining of the uterus where the embryo implants and grows during pregnancy.
- It prepares every month for embryo implantation
- A healthy lining is essential for successful pregnancy
- Any inflammation or infection can disrupt implantation
WHAT IS CHRONIC ENDOMETRITIS?
Chronic Endometritis is a long-standing inflammation of the endometrial lining caused by bacterial infection in the uterus.
- Often asymptomatic (no clear symptoms)
- Not easily detected with standard tests
- Can interfere with embryo implantation
- May increase risk of miscarriage
HOW ALICE HELPS IN FERTILITY
ALICE improves reproductive outcomes by:
- Detecting hidden uterine infections
- Treating chronic inflammation of the endometrium
- Improving uterine environment for implantation
- Reducing risk of IVF failure and miscarriage
- Supporting successful embryo implantation
Cycle Planning
The test is scheduled during a natural or mock cycle, similar to embryo transfer timing.
Endometrial Sample Collection
A small sample of the uterine lining is collected using a thin catheter: Quick and minimally invasive procedure Mild discomfort may occur No anesthesia usually required
Molecular Analysis (ALICE Test)
The sample is analyzed using advanced technology to: Identify specific bacteria causing infection Detect pathogens linked to chronic endometritis Evaluate uterine health at a microbiological level
Result Interpretation
The report indicates: Presence or absence of infection Type of bacteria detected Severity of the condition
Targeted Treatment Plan
Based on results: Specific antibiotics are prescribed Probiotics may be recommended Treatment is personalized for effective recovery
Follow-Up & Confirmation
Repeat testing or evaluation ensures that the infection has been resolved.
Follow-Up & Embryo Transfer Planning
After treatment, the uterine environment is reassessed and embryo transfer is planned under optimal conditions.
Freya Fertility
Our Success Highlights
Improvement in implantation rates after treating chronic endometritis
Increase in pregnancy success after infection management
Committed to Your Parenthood Journey
At Freya Fertility, we understand that hidden infections can impact fertility outcomes. With ALICE testing, we identify and treat these infections precisely, helping create a healthier uterine environment for successful implantation and pregnancy.
FAQs
What is ALICE test?
It is a test that detects bacterial infections in the uterine lining causing chronic endometritis.
Is chronic endometritis serious?
Yes, if untreated, it can affect implantation and increase miscarriage risk.
Is the ALICE test painful?
It involves a minor biopsy, which may cause mild discomfort.
Can chronic endometritis be treated?
Yes, it is treatable with targeted antibiotics.
Who should consider ALICE test?
Patients with repeated IVF failures, implantation issues, or recurrent miscarriages.